Drug interactions
Eluxadoline + Simvastatin
Severity: Moderate
Eluxadoline and Simvastatin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Eluxadoline is an OATP1B1 substrate, and simvastatin acid may inhibit this transporter, though the effect is likely modest. Higher eluxadoline levels could increase constipation and pancreatitis risk.
What this interaction means in plain words
Eluxadoline and Simvastatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Eluxadoline belongs to Gastrointestinal Tract; Simvastatin belongs to Cardiovascular.
Why it happens
Simvastatin may inhibit OATP1B1-mediated hepatic uptake of eluxadoline.
What to do
Monitor for eluxadoline adverse effects such as constipation and abdominal pain. Consider reducing the eluxadoline dose to 75 mg twice daily if OATP1B1 inhibition is a concern.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Simvastatin
- Atazanavir + Simvastatin Contraindicated
- Clarithromycin + Simvastatin Contraindicated
- Cobicistat + Simvastatin Contraindicated
- Cyclosporine + Simvastatin Contraindicated
- Cyclosporin + Simvastatin Contraindicated
- Danazol + Simvastatin Contraindicated
Other interactions of Eluxadoline
Frequently asked questions
Can I take Eluxadoline with Simvastatin?
MediHelp rates the interaction as moderate. Eluxadoline and Simvastatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Eluxadoline is an OATP1B1 substrate, and simvastatin acid may inhibit this transporter, though the effect is likely modest. Higher eluxadoline levels could increase constipation and pancreatitis risk.
How serious is the interaction between Eluxadoline and Simvastatin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for eluxadoline adverse effects such as constipation and abdominal pain. Consider reducing the eluxadoline dose to 75 mg twice daily if OATP1B1 inhibition is a concern.
What other medicines interact with Simvastatin?
MediHelp also lists interactions of Simvastatin with, for example, Atazanavir, Clarithromycin, Cobicistat. The full list is on the Simvastatin page.
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