Drug interactions
Elvitegravir + Posaconazole
Severity: Minor
Elvitegravir and Posaconazole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Posaconazole may raise elvitegravir levels through CYP3A4 inhibition. Elvitegravir has a wide tolerability margin, so the increase is usually not significant.
What this interaction means in plain words
Elvitegravir and Posaconazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Posaconazole inhibits CYP3A4 metabolism of elvitegravir.
What to do
No dose adjustment is generally needed. Monitor for adverse effects, noting that cobicistat-boosted regimens may also raise posaconazole exposure.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Posaconazole
- Artemether + Posaconazole Contraindicated
- Avanafil + Posaconazole Contraindicated
- Cobimetinib + Posaconazole Contraindicated
- Conivaptan + Posaconazole Contraindicated
- Dihydroergotamine intranasal + Posaconazole Contraindicated
- Dihydroergotamine + Posaconazole Contraindicated
Frequently asked questions
Can I take Elvitegravir with Posaconazole?
MediHelp rates the interaction as minor. Elvitegravir and Posaconazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Posaconazole may raise elvitegravir levels through CYP3A4 inhibition. Elvitegravir has a wide tolerability margin, so the increase is usually not significant.
How serious is the interaction between Elvitegravir and Posaconazole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is generally needed. Monitor for adverse effects, noting that cobicistat-boosted regimens may also raise posaconazole exposure.
What other medicines interact with Posaconazole?
MediHelp also lists interactions of Posaconazole with, for example, Artemether, Avanafil, Cobimetinib. The full list is on the Posaconazole page.
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