Drug interactions
Elvitegravir / cobicistat / emtricitabine / tenofovir df + Medroxyprogesterone
Severity: Moderate
Elvitegravir / cobicistat / emtricitabine / tenofovir df and Medroxyprogesterone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cobicistat can increase medroxyprogesterone exposure by inhibiting its metabolism, potentially increasing progestogenic adverse effects.
What this interaction means in plain words
Elvitegravir / cobicistat / emtricitabine / tenofovir df and Medroxyprogesterone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Cobicistat inhibits CYP3A4, which metabolizes medroxyprogesterone.
What to do
Monitor for adverse effects such as mood changes, bleeding irregularities, and bone effects. Consider dose adjustment if clinically indicated.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Medroxyprogesterone
Frequently asked questions
Can I take Elvitegravir / cobicistat / emtricitabine / tenofovir df with Medroxyprogesterone?
MediHelp rates the interaction as moderate. Elvitegravir / cobicistat / emtricitabine / tenofovir df and Medroxyprogesterone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cobicistat can increase medroxyprogesterone exposure by inhibiting its metabolism, potentially increasing progestogenic adverse effects.
How serious is the interaction between Elvitegravir / cobicistat / emtricitabine / tenofovir df and Medroxyprogesterone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for adverse effects such as mood changes, bleeding irregularities, and bone effects. Consider dose adjustment if clinically indicated.
What other medicines interact with Medroxyprogesterone?
MediHelp also lists interactions of Medroxyprogesterone with, for example, Bosentan, Brigatinib, Eslicarbazepine. The full list is on the Medroxyprogesterone page.
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