Drug interactions
Elvitegravir / cobicistat / emtricitabine / tenofovir df + Montelukast
Severity: Minor
Elvitegravir / cobicistat / emtricitabine / tenofovir df and Montelukast: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Montelukast is metabolized by CYP2C8, CYP3A4 and CYP2C9. Cobicistat inhibits CYP3A4 and may raise montelukast exposure modestly, but montelukast has a wide therapeutic margin, so the combination is not contraindicated.
What this interaction means in plain words
Elvitegravir / cobicistat / emtricitabine / tenofovir df and Montelukast have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Cobicistat inhibition of CYP3A4 may modestly raise montelukast levels, partly offset by weak CYP2C9 induction.
What to do
No dose change is needed; monitor for montelukast adverse effects such as neuropsychiatric symptoms or headache.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Montelukast
- Apalutamide + Montelukast Moderate
- Carbamazepine + Montelukast Moderate
- Deferasirox + Montelukast Moderate
- Enzalutamide + Montelukast Moderate
- Fosphenytoin + Montelukast Moderate
- Gemfibrozil + Montelukast Moderate
Frequently asked questions
Can I take Elvitegravir / cobicistat / emtricitabine / tenofovir df with Montelukast?
MediHelp rates the interaction as minor. Elvitegravir / cobicistat / emtricitabine / tenofovir df and Montelukast have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Montelukast is metabolized by CYP2C8, CYP3A4 and CYP2C9. Cobicistat inhibits CYP3A4 and may raise montelukast exposure modestly, but montelukast has a wide therapeutic margin, so the combination is not contraindicated.
How serious is the interaction between Elvitegravir / cobicistat / emtricitabine / tenofovir df and Montelukast?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is needed; monitor for montelukast adverse effects such as neuropsychiatric symptoms or headache.
What other medicines interact with Montelukast?
MediHelp also lists interactions of Montelukast with, for example, Apalutamide, Carbamazepine, Deferasirox. The full list is on the Montelukast page.
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