Drug interactions
Elvitegravir / cobicistat / emtricitabine / tenofovir df + Posaconazole
Severity: Major
Elvitegravir / cobicistat / emtricitabine / tenofovir df and Posaconazole: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cobicistat and elvitegravir are CYP3A-dependent and cobicistat inhibits CYP3A, so posaconazole may raise exposure to the regimen and the regimen may raise posaconazole. This could increase adverse effects of either agent, including QT-related effects.
What this interaction means in plain words
Elvitegravir / cobicistat / emtricitabine / tenofovir df and Posaconazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Mutual CYP3A4 inhibition and substrate overlap between posaconazole and cobicistat.
What to do
Avoid if an alternative is available. If both are needed, monitor posaconazole levels, ECG and tolerability.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Posaconazole
- Artemether + Posaconazole Contraindicated
- Avanafil + Posaconazole Contraindicated
- Cobimetinib + Posaconazole Contraindicated
- Conivaptan + Posaconazole Contraindicated
- Dihydroergotamine intranasal + Posaconazole Contraindicated
- Dihydroergotamine + Posaconazole Contraindicated
Frequently asked questions
Can I take Elvitegravir / cobicistat / emtricitabine / tenofovir df with Posaconazole?
MediHelp rates the interaction as major. Elvitegravir / cobicistat / emtricitabine / tenofovir df and Posaconazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Cobicistat and elvitegravir are CYP3A-dependent and cobicistat inhibits CYP3A, so posaconazole may raise exposure to the regimen and the regimen may raise posaconazole. This could increase adverse effects of either agent, including QT-related effects.
How serious is the interaction between Elvitegravir / cobicistat / emtricitabine / tenofovir df and Posaconazole?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if an alternative is available. If both are needed, monitor posaconazole levels, ECG and tolerability.
What other medicines interact with Posaconazole?
MediHelp also lists interactions of Posaconazole with, for example, Artemether, Avanafil, Cobimetinib. The full list is on the Posaconazole page.
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