Drug interactions
Elvitegravir / cobicistat / emtricitabine / tenofovir df + Progesterone
Severity: Moderate
Elvitegravir / cobicistat / emtricitabine / tenofovir df and Progesterone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cobicistat inhibits CYP3A4 and can raise progesterone concentrations, increasing progestogenic adverse effects. The hormonal effects and contraceptive or endometrial protection may be altered.
What this interaction means in plain words
Elvitegravir / cobicistat / emtricitabine / tenofovir df and Progesterone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Cobicistat inhibits CYP3A4, reducing progesterone metabolism.
What to do
Monitor for progestogenic adverse effects and adjust the progesterone dose if needed. Use an additional or alternative contraception strategy if used for contraception.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Progesterone
Frequently asked questions
Can I take Elvitegravir / cobicistat / emtricitabine / tenofovir df with Progesterone?
MediHelp rates the interaction as moderate. Elvitegravir / cobicistat / emtricitabine / tenofovir df and Progesterone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cobicistat inhibits CYP3A4 and can raise progesterone concentrations, increasing progestogenic adverse effects. The hormonal effects and contraceptive or endometrial protection may be altered.
How serious is the interaction between Elvitegravir / cobicistat / emtricitabine / tenofovir df and Progesterone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for progestogenic adverse effects and adjust the progesterone dose if needed. Use an additional or alternative contraception strategy if used for contraception.
What other medicines interact with Progesterone?
MediHelp also lists interactions of Progesterone with, for example, Apalutamide, Carbamazepine, Enzalutamide. The full list is on the Progesterone page.
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