Drug interactions
Elvitegravir / cobicistat / emtricitabine / tenofovir df + Propofol
Severity: Minor
Elvitegravir / cobicistat / emtricitabine / tenofovir df and Propofol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Propofol is mainly glucuronidated, with minor CYP2B6 and CYP2C9 involvement, and cobicistat is a strong CYP3A4 inhibitor, so no meaningful change in propofol exposure is expected. Any interaction is theoretical and not documented clinically.
What this interaction means in plain words
Elvitegravir / cobicistat / emtricitabine / tenofovir df and Propofol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Theoretical effect on minor oxidative pathways of propofol; no established clinically relevant mechanism.
What to do
No dose adjustment is required; titrate propofol to clinical effect as usual.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Propofol
Frequently asked questions
Can I take Elvitegravir / cobicistat / emtricitabine / tenofovir df with Propofol?
MediHelp rates the interaction as minor. Elvitegravir / cobicistat / emtricitabine / tenofovir df and Propofol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Propofol is mainly glucuronidated, with minor CYP2B6 and CYP2C9 involvement, and cobicistat is a strong CYP3A4 inhibitor, so no meaningful change in propofol exposure is expected. Any interaction is theoretical and not documented clinically.
How serious is the interaction between Elvitegravir / cobicistat / emtricitabine / tenofovir df and Propofol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is required; titrate propofol to clinical effect as usual.
What other medicines interact with Propofol?
MediHelp also lists interactions of Propofol with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Propofol page.
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