Drug interactions
Empagliflozin-linagliptin + Enzalutamide
Severity: Moderate
Empagliflozin-linagliptin and Enzalutamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Enzalutamide is a strong CYP3A4 inducer and also induces P-glycoprotein, so it can lower linagliptin exposure and weaken glycemic control.
What this interaction means in plain words
Empagliflozin-linagliptin and Enzalutamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Empagliflozin-linagliptin belongs to Endocrine; Enzalutamide belongs to Endocrine.
Why it happens
Induction of CYP3A4 and P-glycoprotein increases linagliptin clearance.
What to do
Monitor glucose and HbA1c, and consider an alternative antidiabetic agent if control worsens.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Empagliflozin-linagliptin
Other interactions of Enzalutamide
- Doravirine + Enzalutamide Contraindicated
- Elbasvir / grazoprevir + Enzalutamide Contraindicated
- Ensitrelvir + Enzalutamide Contraindicated
- Enzalutamide + Fostemsavir Contraindicated
- Enzalutamide + Isavuconazonium Contraindicated
- Enzalutamide + Lenacapavir Contraindicated
Frequently asked questions
Can I take Empagliflozin-linagliptin with Enzalutamide?
MediHelp rates the interaction as moderate. Empagliflozin-linagliptin and Enzalutamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Enzalutamide is a strong CYP3A4 inducer and also induces P-glycoprotein, so it can lower linagliptin exposure and weaken glycemic control.
How serious is the interaction between Empagliflozin-linagliptin and Enzalutamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor glucose and HbA1c, and consider an alternative antidiabetic agent if control worsens.
What other medicines interact with Empagliflozin-linagliptin?
MediHelp also lists interactions of Empagliflozin-linagliptin with, for example, Fosphenytoin, Rifampin, Rifapentine. The full list is on the Empagliflozin-linagliptin page.
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