Drug interactions
Empagliflozin-metformin + Everolimus
Severity: Moderate
Empagliflozin-metformin and Everolimus: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Everolimus commonly causes hyperglycemia and hyperlipidemia, which can counteract the glucose-lowering effect of empagliflozin-metformin. Patients may need more intensive antidiabetic therapy while on treatment.
What this interaction means in plain words
Empagliflozin-metformin and Everolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Empagliflozin-metformin belongs to Endocrine; Everolimus belongs to Oncology.
Why it happens
mTOR inhibition causes insulin resistance and reduced beta-cell function, opposing the effect of antidiabetic drugs.
What to do
Check fasting glucose before starting everolimus and monitor it regularly during treatment. Intensify antidiabetic therapy if hyperglycemia develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Empagliflozin-metformin
Other interactions of Everolimus
- Bcg vaccine live + Everolimus Contraindicated
- Everolimus + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Everolimus + Levoketoconazole Contraindicated
- Everolimus + Measles mumps and rubella vaccine live Contraindicated
- Everolimus + Measles mumps rubella and varicella vaccine live Contraindicated
- Everolimus + Measles vaccine Contraindicated
Frequently asked questions
Can I take Empagliflozin-metformin with Everolimus?
MediHelp rates the interaction as moderate. Empagliflozin-metformin and Everolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Everolimus commonly causes hyperglycemia and hyperlipidemia, which can counteract the glucose-lowering effect of empagliflozin-metformin. Patients may need more intensive antidiabetic therapy while on treatment.
How serious is the interaction between Empagliflozin-metformin and Everolimus?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check fasting glucose before starting everolimus and monitor it regularly during treatment. Intensify antidiabetic therapy if hyperglycemia develops.
What other medicines interact with Empagliflozin-metformin?
MediHelp also lists interactions of Empagliflozin-metformin with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Empagliflozin-metformin page.
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