Drug interactions
Empagliflozin-metformin + Glipizide
Severity: Moderate
Empagliflozin-metformin and Glipizide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining an SGLT2 inhibitor with a sulfonylurea increases the risk of hypoglycemia. The risk is greatest early in therapy and in patients with poor intake or renal impairment.
What this interaction means in plain words
Empagliflozin-metformin and Glipizide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Empagliflozin-metformin belongs to Endocrine; Glipizide belongs to Endocrine.
Why it happens
Additive glucose lowering from insulin secretion stimulation by the sulfonylurea and urinary glucose excretion by empagliflozin.
What to do
Consider lowering the glipizide dose when starting empagliflozin and counsel the patient on hypoglycemia recognition and glucose monitoring.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Empagliflozin-metformin
Other interactions of Glipizide
Frequently asked questions
Can I take Empagliflozin-metformin with Glipizide?
MediHelp rates the interaction as moderate. Empagliflozin-metformin and Glipizide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Combining an SGLT2 inhibitor with a sulfonylurea increases the risk of hypoglycemia. The risk is greatest early in therapy and in patients with poor intake or renal impairment.
How serious is the interaction between Empagliflozin-metformin and Glipizide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider lowering the glipizide dose when starting empagliflozin and counsel the patient on hypoglycemia recognition and glucose monitoring.
What other medicines interact with Empagliflozin-metformin?
MediHelp also lists interactions of Empagliflozin-metformin with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Empagliflozin-metformin page.
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