Drug interactions
Empagliflozin-metformin + Hydrochlorothiazide
Severity: Moderate
Empagliflozin-metformin and Hydrochlorothiazide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Empagliflozin has diuretic effects that add to those of hydrochlorothiazide, which increases the risk of volume depletion, hypotension and electrolyte disturbance. Thiazides may also modestly raise blood glucose.
What this interaction means in plain words
Empagliflozin-metformin and Hydrochlorothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Empagliflozin-metformin belongs to Endocrine; Hydrochlorothiazide belongs to Cardiovascular.
Why it happens
Additive diuretic and natriuretic effects; thiazides may also impair glucose tolerance.
What to do
Assess volume status and renal function at baseline and after initiation. Monitor blood pressure, electrolytes and glucose, and reduce the diuretic dose if volume depletion occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Empagliflozin-metformin
Other interactions of Hydrochlorothiazide
Frequently asked questions
Can I take Empagliflozin-metformin with Hydrochlorothiazide?
MediHelp rates the interaction as moderate. Empagliflozin-metformin and Hydrochlorothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Empagliflozin has diuretic effects that add to those of hydrochlorothiazide, which increases the risk of volume depletion, hypotension and electrolyte disturbance. Thiazides may also modestly raise blood glucose.
How serious is the interaction between Empagliflozin-metformin and Hydrochlorothiazide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Assess volume status and renal function at baseline and after initiation. Monitor blood pressure, electrolytes and glucose, and reduce the diuretic dose if volume depletion occurs.
What other medicines interact with Empagliflozin-metformin?
MediHelp also lists interactions of Empagliflozin-metformin with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Empagliflozin-metformin page.
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