Drug interactions
Empagliflozin-metformin + Lopinavir
Severity: Moderate
Empagliflozin-metformin and Lopinavir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Protease inhibitors are associated with insulin resistance and hyperglycemia. Glycemic control in patients on empagliflozin-metformin may deteriorate after lopinavir/ritonavir is started.
What this interaction means in plain words
Empagliflozin-metformin and Lopinavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Empagliflozin-metformin belongs to Endocrine; Lopinavir belongs to Anti Virals.
Why it happens
Protease inhibitors impair insulin-mediated glucose uptake (partly via GLUT4 inhibition), causing insulin resistance that opposes antidiabetic therapy.
What to do
Check blood glucose and HbA1c after starting lopinavir and adjust antidiabetic treatment as needed. Counsel the patient on symptoms of hyperglycemia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Empagliflozin-metformin
Other interactions of Lopinavir
- Alfuzosin + Lopinavir Contraindicated
- Avanafil + Lopinavir Contraindicated
- Cisapride + Lopinavir Contraindicated
- Dronedarone + Lopinavir Contraindicated
- Eletriptan + Lopinavir Contraindicated
- Eplerenone + Lopinavir Contraindicated
Frequently asked questions
Can I take Empagliflozin-metformin with Lopinavir?
MediHelp rates the interaction as moderate. Empagliflozin-metformin and Lopinavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Protease inhibitors are associated with insulin resistance and hyperglycemia. Glycemic control in patients on empagliflozin-metformin may deteriorate after lopinavir/ritonavir is started.
How serious is the interaction between Empagliflozin-metformin and Lopinavir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check blood glucose and HbA1c after starting lopinavir and adjust antidiabetic treatment as needed. Counsel the patient on symptoms of hyperglycemia.
What other medicines interact with Empagliflozin-metformin?
MediHelp also lists interactions of Empagliflozin-metformin with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Empagliflozin-metformin page.
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