Drug interactions
Empagliflozin-metformin + Ondansetron
Severity: Minor
Empagliflozin-metformin and Ondansetron: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ondansetron may raise metformin exposure by interfering with renal tubular secretion, though the clinical significance is modest. Increased metformin levels could add to gastrointestinal effects and, in susceptible patients, lactic acidosis risk.
What this interaction means in plain words
Empagliflozin-metformin and Ondansetron have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Empagliflozin-metformin belongs to Endocrine; Ondansetron belongs to Gastrointestinal Tract.
Why it happens
Inhibition of renal organic cation transporters and MATE proteins reduces metformin tubular secretion.
What to do
No dose change is usually needed; monitor glucose and renal function in patients with impaired kidney function.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Empagliflozin-metformin
Other interactions of Ondansetron
- Apomorphine + Ondansetron Contraindicated
- Ondansetron + Thioridazine Contraindicated
- Ondansetron + Vandetanib Contraindicated
- Adagrasib + Ondansetron Major
- Amiodarone + Ondansetron Major
- Amisulpride + Ondansetron Major
Frequently asked questions
Can I take Empagliflozin-metformin with Ondansetron?
MediHelp rates the interaction as minor. Empagliflozin-metformin and Ondansetron have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Ondansetron may raise metformin exposure by interfering with renal tubular secretion, though the clinical significance is modest. Increased metformin levels could add to gastrointestinal effects and, in susceptible patients, lactic acidosis risk.
How serious is the interaction between Empagliflozin-metformin and Ondansetron?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is usually needed; monitor glucose and renal function in patients with impaired kidney function.
What other medicines interact with Empagliflozin-metformin?
MediHelp also lists interactions of Empagliflozin-metformin with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Empagliflozin-metformin page.
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