Drug interactions
Empagliflozin-metformin + Pegvisomant
Severity: Minor
Empagliflozin-metformin and Pegvisomant: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pegvisomant, used in acromegaly, reduces IGF-1 activity and improves glucose tolerance as growth hormone excess is controlled. In patients taking glucose-lowering drugs this can increase the glucose-lowering effect and may lead to hypoglycemia.
What this interaction means in plain words
Empagliflozin-metformin and Pegvisomant have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Empagliflozin-metformin belongs to Endocrine; Pegvisomant belongs to Endocrine.
Why it happens
Additive pharmacodynamic effect: pegvisomant blocks growth hormone receptor action, improving insulin sensitivity.
What to do
Monitor blood glucose after starting pegvisomant and reduce doses of antidiabetic drugs if glucose falls. Reassess glycemic regimen as acromegaly comes under control.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Empagliflozin-metformin and Pegvisomant, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Empagliflozin-metformin
Other interactions of Pegvisomant
- Alogliptin-metformin + Pegvisomant Moderate
- Alogliptin-pioglitazone + Pegvisomant Moderate
- Chlorpropamide + Pegvisomant Moderate
- Codeine + Pegvisomant Moderate
- Dapagliflozin-metformin + Pegvisomant Moderate
- Ertugliflozin-sitagliptin + Pegvisomant Moderate
Frequently asked questions
Can I take Empagliflozin-metformin with Pegvisomant?
MediHelp rates the interaction as minor. Empagliflozin-metformin and Pegvisomant have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Pegvisomant, used in acromegaly, reduces IGF-1 activity and improves glucose tolerance as growth hormone excess is controlled. In patients taking glucose-lowering drugs this can increase the glucose-lowering effect and may lead to hypoglycemia.
How serious is the interaction between Empagliflozin-metformin and Pegvisomant?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose after starting pegvisomant and reduce doses of antidiabetic drugs if glucose falls. Reassess glycemic regimen as acromegaly comes under control.
What other medicines interact with Empagliflozin-metformin?
MediHelp also lists interactions of Empagliflozin-metformin with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Empagliflozin-metformin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
