Drug interactions
Emtricitabine + Mefenamic acid
Severity: Moderate
Emtricitabine and Mefenamic acid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents are renally eliminated, and NSAIDs can reduce renal function, potentially increasing emtricitabine exposure. Risk is greater with high or multiple NSAID doses and pre-existing renal impairment.
What this interaction means in plain words
Emtricitabine and Mefenamic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Emtricitabine belongs to Anti Virals; Mefenamic acid belongs to Musculoskeletal.
Why it happens
Competition for tubular secretion and NSAID-related reduction in glomerular filtration reduce renal clearance.
What to do
Monitor renal function and consider alternatives to NSAIDs, especially with high-dose or prolonged use.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mefenamic acid
- Ketorolac intranasal + Mefenamic acid Contraindicated
- Ketorolac + Mefenamic acid Contraindicated
- Aceclofenac + Mefenamic acid Major
- Acemetacin + Mefenamic acid Major
- Acetylsalicylic acid + Mefenamic acid Major
- Alteplase + Mefenamic acid Major
Other interactions of Emtricitabine
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Emtricitabine Contraindicated
- Atidarsagene autotemcel + Emtricitabine Major
- Betibeglogene autotemcel + Emtricitabine Major
- Elivaldogene autotemcel + Emtricitabine Major
- Emtricitabine + Lamivudine Major
- Emtricitabine + Lovotibeglogene autotemcel Major
Frequently asked questions
Can I take Emtricitabine with Mefenamic acid?
MediHelp rates the interaction as moderate. Emtricitabine and Mefenamic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents are renally eliminated, and NSAIDs can reduce renal function, potentially increasing emtricitabine exposure. Risk is greater with high or multiple NSAID doses and pre-existing renal impairment.
How serious is the interaction between Emtricitabine and Mefenamic acid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor renal function and consider alternatives to NSAIDs, especially with high-dose or prolonged use.
What other medicines interact with Mefenamic acid?
MediHelp also lists interactions of Mefenamic acid with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Mefenamic acid page.
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