Drug interactions
Emtricitabine + Piroxicam
Severity: Moderate
Emtricitabine and Piroxicam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Emtricitabine is eliminated mainly by the kidney through filtration and tubular secretion, and NSAIDs can lower renal perfusion. Concurrent use, particularly with high or repeated NSAID doses, may raise emtricitabine exposure and increase the risk of renal adverse effects.
What this interaction means in plain words
Emtricitabine and Piroxicam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Emtricitabine belongs to Anti Virals; Piroxicam belongs to Musculoskeletal.
Why it happens
NSAID-related reduction in renal prostaglandin-dependent perfusion and possible competition for renal tubular secretion reduce emtricitabine clearance.
What to do
Where possible, use an alternative analgesic such as paracetamol or limit NSAID dose and duration. Monitor renal function (serum creatinine) during combined use.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Piroxicam
- Ketorolac intranasal + Piroxicam Contraindicated
- Ketorolac + Piroxicam Contraindicated
- Aceclofenac + Piroxicam Major
- Acemetacin + Piroxicam Major
- Acetylsalicylic acid + Piroxicam Major
- Alteplase + Piroxicam Major
Other interactions of Emtricitabine
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Emtricitabine Contraindicated
- Atidarsagene autotemcel + Emtricitabine Major
- Betibeglogene autotemcel + Emtricitabine Major
- Elivaldogene autotemcel + Emtricitabine Major
- Emtricitabine + Lamivudine Major
- Emtricitabine + Lovotibeglogene autotemcel Major
Frequently asked questions
Can I take Emtricitabine with Piroxicam?
MediHelp rates the interaction as moderate. Emtricitabine and Piroxicam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Emtricitabine is eliminated mainly by the kidney through filtration and tubular secretion, and NSAIDs can lower renal perfusion. Concurrent use, particularly with high or repeated NSAID doses, may raise emtricitabine exposure and increase the risk of renal adverse effects.
How serious is the interaction between Emtricitabine and Piroxicam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Where possible, use an alternative analgesic such as paracetamol or limit NSAID dose and duration. Monitor renal function (serum creatinine) during combined use.
What other medicines interact with Piroxicam?
MediHelp also lists interactions of Piroxicam with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Piroxicam page.
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