Drug interactions
Enalapril-hydrochlorothiazide + Ephedrine
Severity: Moderate
Enalapril-hydrochlorothiazide and Ephedrine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ephedrine can modestly lower serum potassium through beta-adrenergic effects, adding to thiazide-induced hypokalemia. It may also raise blood pressure and so reduce the antihypertensive effect of the combination.
What this interaction means in plain words
Enalapril-hydrochlorothiazide and Ephedrine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Enalapril-hydrochlorothiazide belongs to Cardiovascular; Ephedrine belongs to Cardiovascular.
Why it happens
Beta2-mediated cellular potassium uptake plus thiazide renal potassium loss; sympathomimetic pressor effect opposes antihypertensives.
What to do
Monitor blood pressure and serum potassium when ephedrine is used regularly or in high doses. Correct hypokalemia in patients with cardiac disease.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Enalapril-hydrochlorothiazide
- Aliskiren + Enalapril-hydrochlorothiazide Contraindicated
- Dofetilide + Enalapril-hydrochlorothiazide Contraindicated
- Enalapril-hydrochlorothiazide + Protein a column Contraindicated
- Enalapril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Amifostine + Enalapril-hydrochlorothiazide Major
- Amiloride + Enalapril-hydrochlorothiazide Major
Other interactions of Ephedrine
- Ephedrine + Isocarboxazid Contraindicated
- Ephedrine + Phenelzine Contraindicated
- Ephedrine + Procarbazine Contraindicated
- Ephedrine + Rasagiline Contraindicated
- Ephedrine + Selegiline Contraindicated
- Ephedrine + Tranylcypromine Contraindicated
Frequently asked questions
Can I take Enalapril-hydrochlorothiazide with Ephedrine?
MediHelp rates the interaction as moderate. Enalapril-hydrochlorothiazide and Ephedrine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ephedrine can modestly lower serum potassium through beta-adrenergic effects, adding to thiazide-induced hypokalemia. It may also raise blood pressure and so reduce the antihypertensive effect of the combination.
How serious is the interaction between Enalapril-hydrochlorothiazide and Ephedrine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and serum potassium when ephedrine is used regularly or in high doses. Correct hypokalemia in patients with cardiac disease.
What other medicines interact with Enalapril-hydrochlorothiazide?
MediHelp also lists interactions of Enalapril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Protein a column. The full list is on the Enalapril-hydrochlorothiazide page.
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