Drug interactions
Enalapril-hydrochlorothiazide + Esmolol
Severity: Minor
Enalapril-hydrochlorothiazide and Esmolol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Esmolol adds to the blood pressure lowering effect and may cause hypotension or bradycardia when used with enalapril and hydrochlorothiazide. Beta blockers can slightly raise potassium while thiazides lower it.
What this interaction means in plain words
Enalapril-hydrochlorothiazide and Esmolol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Enalapril-hydrochlorothiazide belongs to Cardiovascular; Esmolol belongs to Cardiovascular.
Why it happens
Additive hemodynamic effects of beta blockade, ACE inhibition and diuresis.
What to do
Monitor blood pressure and heart rate during esmolol infusion, and check potassium if used over a prolonged period.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Enalapril-hydrochlorothiazide
- Aliskiren + Enalapril-hydrochlorothiazide Contraindicated
- Dofetilide + Enalapril-hydrochlorothiazide Contraindicated
- Enalapril-hydrochlorothiazide + Protein a column Contraindicated
- Enalapril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Amifostine + Enalapril-hydrochlorothiazide Major
- Amiloride + Enalapril-hydrochlorothiazide Major
Other interactions of Esmolol
- Acebutolol + Esmolol Major
- Amifostine + Esmolol Major
- Amiodarone + Esmolol Major
- Celiprolol + Esmolol Major
- Diltiazem + Esmolol Major
- Epinephrine racemic + Esmolol Major
Frequently asked questions
Can I take Enalapril-hydrochlorothiazide with Esmolol?
MediHelp rates the interaction as minor. Enalapril-hydrochlorothiazide and Esmolol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Esmolol adds to the blood pressure lowering effect and may cause hypotension or bradycardia when used with enalapril and hydrochlorothiazide. Beta blockers can slightly raise potassium while thiazides lower it.
How serious is the interaction between Enalapril-hydrochlorothiazide and Esmolol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate during esmolol infusion, and check potassium if used over a prolonged period.
What other medicines interact with Enalapril-hydrochlorothiazide?
MediHelp also lists interactions of Enalapril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Protein a column. The full list is on the Enalapril-hydrochlorothiazide page.
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