Drug interactions
Enalapril-hydrochlorothiazide + Fluphenazine
Severity: Minor
Enalapril-hydrochlorothiazide and Fluphenazine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Phenothiazines such as fluphenazine can cause orthostatic hypotension through alpha-adrenergic blockade. Combined with an ACE inhibitor and thiazide diuretic, blood pressure lowering may be additive, causing dizziness or falls, especially in older adults.
What this interaction means in plain words
Enalapril-hydrochlorothiazide and Fluphenazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Enalapril-hydrochlorothiazide belongs to Cardiovascular; Fluphenazine belongs to Central Nervous System.
Why it happens
Additive hypotensive effects from alpha-adrenergic blockade by fluphenazine and the antihypertensive actions of enalapril and hydrochlorothiazide.
What to do
Monitor blood pressure and orthostatic symptoms when starting or increasing fluphenazine; counsel patients to rise slowly.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Enalapril-hydrochlorothiazide
- Aliskiren + Enalapril-hydrochlorothiazide Contraindicated
- Dofetilide + Enalapril-hydrochlorothiazide Contraindicated
- Enalapril-hydrochlorothiazide + Protein a column Contraindicated
- Enalapril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Amifostine + Enalapril-hydrochlorothiazide Major
- Amiloride + Enalapril-hydrochlorothiazide Major
Other interactions of Fluphenazine
- Arsenic trioxide + Fluphenazine Contraindicated
- Dofetilide + Fluphenazine Contraindicated
- Fluphenazine + Ibutilide Contraindicated
- Fluphenazine + Pimozide Contraindicated
- Adagrasib + Fluphenazine Major
- Alfentanil + Fluphenazine Major
Frequently asked questions
Can I take Enalapril-hydrochlorothiazide with Fluphenazine?
MediHelp rates the interaction as minor. Enalapril-hydrochlorothiazide and Fluphenazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Phenothiazines such as fluphenazine can cause orthostatic hypotension through alpha-adrenergic blockade. Combined with an ACE inhibitor and thiazide diuretic, blood pressure lowering may be additive, causing dizziness or falls, especially in older adults.
How serious is the interaction between Enalapril-hydrochlorothiazide and Fluphenazine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and orthostatic symptoms when starting or increasing fluphenazine; counsel patients to rise slowly.
What other medicines interact with Enalapril-hydrochlorothiazide?
MediHelp also lists interactions of Enalapril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Protein a column. The full list is on the Enalapril-hydrochlorothiazide page.
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