Drug interactions
Enalapril-hydrochlorothiazide + Gentamicin
Severity: Moderate
Enalapril-hydrochlorothiazide and Gentamicin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hydrochlorothiazide may cause hypokalemia and hypomagnesemia and volume depletion, which increases the risk of gentamicin nephrotoxicity. ACE inhibitors further impair renal autoregulation, so kidney injury becomes more likely.
What this interaction means in plain words
Enalapril-hydrochlorothiazide and Gentamicin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Enalapril-hydrochlorothiazide belongs to Cardiovascular; Gentamicin belongs to Anti Bacterial.
Why it happens
Additive nephrotoxic risk from volume depletion and ACE inhibition, with electrolyte disturbance from the diuretic.
What to do
Monitor renal function, gentamicin levels, potassium and magnesium, and ensure adequate hydration. Consider temporarily holding the diuretic and ACE inhibitor in unwell patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Enalapril-hydrochlorothiazide
- Aliskiren + Enalapril-hydrochlorothiazide Contraindicated
- Dofetilide + Enalapril-hydrochlorothiazide Contraindicated
- Enalapril-hydrochlorothiazide + Protein a column Contraindicated
- Enalapril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Amifostine + Enalapril-hydrochlorothiazide Major
- Amiloride + Enalapril-hydrochlorothiazide Major
Other interactions of Gentamicin
- Cidofovir + Gentamicin Contraindicated
- Adefovir + Gentamicin Major
- Amikacin + Gentamicin Major
- Amlodipine-hydrochlorothiazide-valsartan + Gentamicin Major
- Amphotericin b deoxycholate + Gentamicin Major
- Amphotericin b + Gentamicin Major
Frequently asked questions
Can I take Enalapril-hydrochlorothiazide with Gentamicin?
MediHelp rates the interaction as moderate. Enalapril-hydrochlorothiazide and Gentamicin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Hydrochlorothiazide may cause hypokalemia and hypomagnesemia and volume depletion, which increases the risk of gentamicin nephrotoxicity. ACE inhibitors further impair renal autoregulation, so kidney injury becomes more likely.
How serious is the interaction between Enalapril-hydrochlorothiazide and Gentamicin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor renal function, gentamicin levels, potassium and magnesium, and ensure adequate hydration. Consider temporarily holding the diuretic and ACE inhibitor in unwell patients.
What other medicines interact with Enalapril-hydrochlorothiazide?
MediHelp also lists interactions of Enalapril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Protein a column. The full list is on the Enalapril-hydrochlorothiazide page.
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