Drug interactions
Enalapril-hydrochlorothiazide + Labetalol
Severity: Minor
Enalapril-hydrochlorothiazide and Labetalol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Labetalol and the enalapril-hydrochlorothiazide combination both lower blood pressure, so additive hypotension can occur, especially when starting treatment. Potassium effects are small and not clearly clinically relevant.
What this interaction means in plain words
Enalapril-hydrochlorothiazide and Labetalol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Enalapril-hydrochlorothiazide belongs to Cardiovascular; Labetalol belongs to Cardiovascular.
Why it happens
Additive antihypertensive effects through different mechanisms (beta/alpha blockade, ACE inhibition and diuresis).
What to do
This combination is commonly used intentionally; monitor blood pressure and heart rate when starting or adjusting doses. Watch for orthostatic symptoms.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Enalapril-hydrochlorothiazide
- Aliskiren + Enalapril-hydrochlorothiazide Contraindicated
- Dofetilide + Enalapril-hydrochlorothiazide Contraindicated
- Enalapril-hydrochlorothiazide + Protein a column Contraindicated
- Enalapril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Amifostine + Enalapril-hydrochlorothiazide Major
- Amiloride + Enalapril-hydrochlorothiazide Major
Other interactions of Labetalol
- Amifostine + Labetalol Major
- Amiodarone + Labetalol Major
- Atenolol-chlorthalidone + Labetalol Major
- Atenolol + Labetalol Major
- Betaxolol + Labetalol Major
- Bisoprolol + Labetalol Major
Frequently asked questions
Can I take Enalapril-hydrochlorothiazide with Labetalol?
MediHelp rates the interaction as minor. Enalapril-hydrochlorothiazide and Labetalol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Labetalol and the enalapril-hydrochlorothiazide combination both lower blood pressure, so additive hypotension can occur, especially when starting treatment. Potassium effects are small and not clearly clinically relevant.
How serious is the interaction between Enalapril-hydrochlorothiazide and Labetalol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: This combination is commonly used intentionally; monitor blood pressure and heart rate when starting or adjusting doses. Watch for orthostatic symptoms.
What other medicines interact with Enalapril-hydrochlorothiazide?
MediHelp also lists interactions of Enalapril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Protein a column. The full list is on the Enalapril-hydrochlorothiazide page.
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