Drug interactions
Enalapril-hydrochlorothiazide + Letermovir
Severity: Minor
Enalapril-hydrochlorothiazide and Letermovir: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Letermovir inhibits OATP1B1/1B3 and may raise plasma concentrations of enalapril and its active metabolite. This could enhance blood pressure lowering, though the clinical impact is probably small.
What this interaction means in plain words
Enalapril-hydrochlorothiazide and Letermovir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Enalapril-hydrochlorothiazide belongs to Cardiovascular; Letermovir belongs to Anti Virals.
Why it happens
Inhibition of hepatic OATP1B1/3 uptake transporters by letermovir.
What to do
No empirical dose change is needed; monitor blood pressure and renal function during letermovir therapy.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Enalapril-hydrochlorothiazide
- Aliskiren + Enalapril-hydrochlorothiazide Contraindicated
- Dofetilide + Enalapril-hydrochlorothiazide Contraindicated
- Enalapril-hydrochlorothiazide + Protein a column Contraindicated
- Enalapril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Amifostine + Enalapril-hydrochlorothiazide Major
- Amiloride + Enalapril-hydrochlorothiazide Major
Other interactions of Letermovir
- Ergotamine + Letermovir Contraindicated
- Letermovir + Pimozide Contraindicated
- Apalutamide + Letermovir Major
- Atorvastatin + Letermovir Major
- Carbamazepine + Letermovir Major
- Colchicine + Letermovir Major
Frequently asked questions
Can I take Enalapril-hydrochlorothiazide with Letermovir?
MediHelp rates the interaction as minor. Enalapril-hydrochlorothiazide and Letermovir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Letermovir inhibits OATP1B1/1B3 and may raise plasma concentrations of enalapril and its active metabolite. This could enhance blood pressure lowering, though the clinical impact is probably small.
How serious is the interaction between Enalapril-hydrochlorothiazide and Letermovir?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No empirical dose change is needed; monitor blood pressure and renal function during letermovir therapy.
What other medicines interact with Enalapril-hydrochlorothiazide?
MediHelp also lists interactions of Enalapril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Protein a column. The full list is on the Enalapril-hydrochlorothiazide page.
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