Drug interactions
Enalapril-hydrochlorothiazide + Liraglutide
Severity: Moderate
Enalapril-hydrochlorothiazide and Liraglutide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thiazide diuretics can impair glucose tolerance and may reduce the glycemic benefit of liraglutide. ACE inhibitors may slightly enhance glucose lowering. Liraglutide-related nausea, vomiting or diarrhea with volume depletion can also raise the risk of acute kidney injury with an ACE inhibitor and diuretic.
What this interaction means in plain words
Enalapril-hydrochlorothiazide and Liraglutide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Enalapril-hydrochlorothiazide belongs to Cardiovascular; Liraglutide belongs to Endocrine.
Why it happens
Thiazides reduce insulin sensitivity while ACE inhibition may improve it, giving variable glycemic effects; GI fluid losses add renal risk.
What to do
Monitor glycemic control and renal function, particularly when starting or changing doses. Advise maintaining hydration during GI side effects.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Enalapril-hydrochlorothiazide
- Aliskiren + Enalapril-hydrochlorothiazide Contraindicated
- Dofetilide + Enalapril-hydrochlorothiazide Contraindicated
- Enalapril-hydrochlorothiazide + Protein a column Contraindicated
- Enalapril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Amifostine + Enalapril-hydrochlorothiazide Major
- Amiloride + Enalapril-hydrochlorothiazide Major
Other interactions of Liraglutide
Frequently asked questions
Can I take Enalapril-hydrochlorothiazide with Liraglutide?
MediHelp rates the interaction as moderate. Enalapril-hydrochlorothiazide and Liraglutide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Thiazide diuretics can impair glucose tolerance and may reduce the glycemic benefit of liraglutide. ACE inhibitors may slightly enhance glucose lowering. Liraglutide-related nausea, vomiting or diarrhea with volume depletion can also raise the risk of acute kidney injury with an ACE inhibitor and diuretic.
How serious is the interaction between Enalapril-hydrochlorothiazide and Liraglutide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor glycemic control and renal function, particularly when starting or changing doses. Advise maintaining hydration during GI side effects.
What other medicines interact with Enalapril-hydrochlorothiazide?
MediHelp also lists interactions of Enalapril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Protein a column. The full list is on the Enalapril-hydrochlorothiazide page.
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