Drug interactions
Enalapril-hydrochlorothiazide + Lornoxicam
Severity: Major
Enalapril-hydrochlorothiazide and Lornoxicam: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs such as lornoxicam reduce the antihypertensive effect of ACE inhibitors and thiazides and can impair renal function. The combination of an NSAID, ACE inhibitor and diuretic carries a recognized risk of acute kidney injury and hyperkalemia, especially in older or volume-depleted patients.
What this interaction means in plain words
Enalapril-hydrochlorothiazide and Lornoxicam can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Enalapril-hydrochlorothiazide belongs to Cardiovascular; Lornoxicam belongs to Musculoskeletal.
Why it happens
NSAIDs inhibit prostaglandin synthesis, reducing renal perfusion and sodium excretion and opposing the effects of ACE inhibitors and diuretics.
What to do
Avoid or use the shortest NSAID course at the lowest dose; ensure adequate hydration. Monitor blood pressure, serum creatinine and potassium.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Enalapril-hydrochlorothiazide
- Aliskiren + Enalapril-hydrochlorothiazide Contraindicated
- Dofetilide + Enalapril-hydrochlorothiazide Contraindicated
- Enalapril-hydrochlorothiazide + Protein a column Contraindicated
- Enalapril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Amifostine + Enalapril-hydrochlorothiazide Major
- Amiloride + Enalapril-hydrochlorothiazide Major
Other interactions of Lornoxicam
Frequently asked questions
Can I take Enalapril-hydrochlorothiazide with Lornoxicam?
MediHelp rates the interaction as major. Enalapril-hydrochlorothiazide and Lornoxicam can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. NSAIDs such as lornoxicam reduce the antihypertensive effect of ACE inhibitors and thiazides and can impair renal function. The combination of an NSAID, ACE inhibitor and diuretic carries a recognized risk of acute kidney injury and hyperkalemia, especially in older or volume-depleted patients.
How serious is the interaction between Enalapril-hydrochlorothiazide and Lornoxicam?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid or use the shortest NSAID course at the lowest dose; ensure adequate hydration. Monitor blood pressure, serum creatinine and potassium.
What other medicines interact with Enalapril-hydrochlorothiazide?
MediHelp also lists interactions of Enalapril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Protein a column. The full list is on the Enalapril-hydrochlorothiazide page.
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