Drug interactions
Enalapril-hydrochlorothiazide + Perphenazine
Severity: Minor
Enalapril-hydrochlorothiazide and Perphenazine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Perphenazine can cause orthostatic hypotension through alpha-adrenergic blockade. With an ACE inhibitor and thiazide, blood pressure lowering may be additive, with dizziness or falls, particularly in older adults.
What this interaction means in plain words
Enalapril-hydrochlorothiazide and Perphenazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Enalapril-hydrochlorothiazide belongs to Cardiovascular; Perphenazine belongs to Central Nervous System.
Why it happens
Additive hypotensive effects from alpha-adrenergic blockade by perphenazine and the antihypertensive actions of enalapril and hydrochlorothiazide.
What to do
Monitor blood pressure and orthostatic symptoms after starting or increasing perphenazine.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Enalapril-hydrochlorothiazide
- Aliskiren + Enalapril-hydrochlorothiazide Contraindicated
- Dofetilide + Enalapril-hydrochlorothiazide Contraindicated
- Enalapril-hydrochlorothiazide + Protein a column Contraindicated
- Enalapril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Amifostine + Enalapril-hydrochlorothiazide Major
- Amiloride + Enalapril-hydrochlorothiazide Major
Other interactions of Perphenazine
- Ibutilide + Perphenazine Contraindicated
- Perphenazine + Pimozide Contraindicated
- Perphenazine + Thioridazine Contraindicated
- Adagrasib + Perphenazine Major
- Alfentanil + Perphenazine Major
- Amiodarone + Perphenazine Major
Frequently asked questions
Can I take Enalapril-hydrochlorothiazide with Perphenazine?
MediHelp rates the interaction as minor. Enalapril-hydrochlorothiazide and Perphenazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Perphenazine can cause orthostatic hypotension through alpha-adrenergic blockade. With an ACE inhibitor and thiazide, blood pressure lowering may be additive, with dizziness or falls, particularly in older adults.
How serious is the interaction between Enalapril-hydrochlorothiazide and Perphenazine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and orthostatic symptoms after starting or increasing perphenazine.
What other medicines interact with Enalapril-hydrochlorothiazide?
MediHelp also lists interactions of Enalapril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Protein a column. The full list is on the Enalapril-hydrochlorothiazide page.
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