Drug interactions
Enalapril-hydrochlorothiazide + Potassium iodide
Severity: Moderate
Enalapril-hydrochlorothiazide and Potassium iodide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Potassium iodide supplies a potassium load that can contribute to hyperkalemia in patients taking an ACE inhibitor. The risk is greater with renal impairment, higher doses or prolonged use. The thiazide component partly counters it.
What this interaction means in plain words
Enalapril-hydrochlorothiazide and Potassium iodide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Enalapril-hydrochlorothiazide belongs to Cardiovascular; Potassium iodide belongs to Endocrine.
Why it happens
ACE inhibition reduces aldosterone-mediated potassium excretion, so the potassium from the iodide salt is retained.
What to do
Monitor serum potassium and renal function when potassium iodide is used for more than a brief course. Reduce or stop one agent if hyperkalemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Enalapril-hydrochlorothiazide
- Aliskiren + Enalapril-hydrochlorothiazide Contraindicated
- Dofetilide + Enalapril-hydrochlorothiazide Contraindicated
- Enalapril-hydrochlorothiazide + Protein a column Contraindicated
- Enalapril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Amifostine + Enalapril-hydrochlorothiazide Major
- Amiloride + Enalapril-hydrochlorothiazide Major
Other interactions of Potassium iodide
- Amiloride + Potassium iodide Moderate
- Amlodipine-benazepril + Potassium iodide Moderate
- Amlodipine-hydrochlorothiazide-valsartan + Potassium iodide Moderate
- Amlodipine-olmesartan-hydrochlorothiazide + Potassium iodide Moderate
- Amlodipine-olmesartan + Potassium iodide Moderate
- Amlodipine-perindopril + Potassium iodide Moderate
Frequently asked questions
Can I take Enalapril-hydrochlorothiazide with Potassium iodide?
MediHelp rates the interaction as moderate. Enalapril-hydrochlorothiazide and Potassium iodide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Potassium iodide supplies a potassium load that can contribute to hyperkalemia in patients taking an ACE inhibitor. The risk is greater with renal impairment, higher doses or prolonged use. The thiazide component partly counters it.
How serious is the interaction between Enalapril-hydrochlorothiazide and Potassium iodide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and renal function when potassium iodide is used for more than a brief course. Reduce or stop one agent if hyperkalemia occurs.
What other medicines interact with Enalapril-hydrochlorothiazide?
MediHelp also lists interactions of Enalapril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Protein a column. The full list is on the Enalapril-hydrochlorothiazide page.
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