Drug interactions
Enalapril-hydrochlorothiazide + Rosiglitazone
Severity: Minor
Enalapril-hydrochlorothiazide and Rosiglitazone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hydrochlorothiazide may raise blood glucose and partly offset the antidiabetic effect of rosiglitazone. The effect is generally modest at usual low thiazide doses.
What this interaction means in plain words
Enalapril-hydrochlorothiazide and Rosiglitazone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Enalapril-hydrochlorothiazide belongs to Cardiovascular; Rosiglitazone belongs to Endocrine.
Why it happens
Pharmacodynamic antagonism: thiazides impair insulin release and sensitivity, partly via potassium depletion.
What to do
Monitor glucose and HbA1c after the thiazide is started or its dose changed, and adjust antidiabetic therapy as needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Enalapril-hydrochlorothiazide
- Aliskiren + Enalapril-hydrochlorothiazide Contraindicated
- Dofetilide + Enalapril-hydrochlorothiazide Contraindicated
- Enalapril-hydrochlorothiazide + Protein a column Contraindicated
- Enalapril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Amifostine + Enalapril-hydrochlorothiazide Major
- Amiloride + Enalapril-hydrochlorothiazide Major
Other interactions of Rosiglitazone
- Insulin aspart protamine / insulin aspart + Rosiglitazone Major
- Insulin aspart-insulin aspart protamine + Rosiglitazone Major
- Insulin aspart + Rosiglitazone Major
- Insulin degludec / insulin aspart + Rosiglitazone Major
- Insulin degludec-insulin aspart + Rosiglitazone Major
- Insulin degludec-liraglutide + Rosiglitazone Major
Frequently asked questions
Can I take Enalapril-hydrochlorothiazide with Rosiglitazone?
MediHelp rates the interaction as minor. Enalapril-hydrochlorothiazide and Rosiglitazone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Hydrochlorothiazide may raise blood glucose and partly offset the antidiabetic effect of rosiglitazone. The effect is generally modest at usual low thiazide doses.
How serious is the interaction between Enalapril-hydrochlorothiazide and Rosiglitazone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor glucose and HbA1c after the thiazide is started or its dose changed, and adjust antidiabetic therapy as needed.
What other medicines interact with Enalapril-hydrochlorothiazide?
MediHelp also lists interactions of Enalapril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Protein a column. The full list is on the Enalapril-hydrochlorothiazide page.
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