Drug interactions
Enalapril-hydrochlorothiazide + Succinylcholine
Severity: Moderate
Enalapril-hydrochlorothiazide and Succinylcholine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Succinylcholine releases potassium from muscle and may raise serum potassium transiently, while thiazide diuretics can cause hypokalemia and alter neuromuscular blockade. Electrolyte disturbance may increase arrhythmia risk and change blocker response during anesthesia.
What this interaction means in plain words
Enalapril-hydrochlorothiazide and Succinylcholine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Enalapril-hydrochlorothiazide belongs to Cardiovascular; Succinylcholine belongs to Musculoskeletal.
Why it happens
Opposing effects on serum potassium and thiazide-related electrolyte changes that modify neuromuscular blockade.
What to do
Check potassium and correct abnormalities before elective anesthesia. Monitor neuromuscular function and ECG perioperatively.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Enalapril-hydrochlorothiazide and Succinylcholine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Enalapril-hydrochlorothiazide
- Aliskiren + Enalapril-hydrochlorothiazide Contraindicated
- Dofetilide + Enalapril-hydrochlorothiazide Contraindicated
- Enalapril-hydrochlorothiazide + Protein a column Contraindicated
- Enalapril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Amifostine + Enalapril-hydrochlorothiazide Major
- Amiloride + Enalapril-hydrochlorothiazide Major
Other interactions of Succinylcholine
Frequently asked questions
Can I take Enalapril-hydrochlorothiazide with Succinylcholine?
MediHelp rates the interaction as moderate. Enalapril-hydrochlorothiazide and Succinylcholine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Succinylcholine releases potassium from muscle and may raise serum potassium transiently, while thiazide diuretics can cause hypokalemia and alter neuromuscular blockade. Electrolyte disturbance may increase arrhythmia risk and change blocker response during anesthesia.
How serious is the interaction between Enalapril-hydrochlorothiazide and Succinylcholine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check potassium and correct abnormalities before elective anesthesia. Monitor neuromuscular function and ECG perioperatively.
What other medicines interact with Enalapril-hydrochlorothiazide?
MediHelp also lists interactions of Enalapril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Protein a column. The full list is on the Enalapril-hydrochlorothiazide page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
