Drug interactions
Enalapril-hydrochlorothiazide + Trofinetide
Severity: Minor
Enalapril-hydrochlorothiazide and Trofinetide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Trofinetide inhibits OATP transporters in vitro and may raise exposure to OATP substrates. Enalapril and its active metabolite are not established as clinically significant OATP substrates, so the relevance is uncertain.
What this interaction means in plain words
Enalapril-hydrochlorothiazide and Trofinetide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Enalapril-hydrochlorothiazide belongs to Cardiovascular; Trofinetide belongs to Central Nervous System.
Why it happens
Possible OATP1B1/1B3 inhibition by trofinetide; clinical effect on enalapril is theoretical.
What to do
No routine adjustment is needed; monitor blood pressure and renal function as usual after trofinetide is started.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Enalapril-hydrochlorothiazide
- Aliskiren + Enalapril-hydrochlorothiazide Contraindicated
- Dofetilide + Enalapril-hydrochlorothiazide Contraindicated
- Enalapril-hydrochlorothiazide + Protein a column Contraindicated
- Enalapril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Amifostine + Enalapril-hydrochlorothiazide Major
- Amiloride + Enalapril-hydrochlorothiazide Major
Other interactions of Trofinetide
Frequently asked questions
Can I take Enalapril-hydrochlorothiazide with Trofinetide?
MediHelp rates the interaction as minor. Enalapril-hydrochlorothiazide and Trofinetide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Trofinetide inhibits OATP transporters in vitro and may raise exposure to OATP substrates. Enalapril and its active metabolite are not established as clinically significant OATP substrates, so the relevance is uncertain.
How serious is the interaction between Enalapril-hydrochlorothiazide and Trofinetide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed; monitor blood pressure and renal function as usual after trofinetide is started.
What other medicines interact with Enalapril-hydrochlorothiazide?
MediHelp also lists interactions of Enalapril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Protein a column. The full list is on the Enalapril-hydrochlorothiazide page.
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