Drug interactions
Encorafenib + Enzalutamide
Severity: Major
Encorafenib and Enzalutamide: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Strong CYP3A4 inducers can lower encorafenib exposure and reduce antitumor efficacy. Enzalutamide is expected to cause this effect.
What this interaction means in plain words
Encorafenib and Enzalutamide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Encorafenib belongs to Oncology; Enzalutamide belongs to Endocrine.
Why it happens
Enzalutamide induces CYP3A4, increasing encorafenib clearance.
What to do
Avoid concomitant use and select an alternative to enzalutamide if possible. Monitor disease response if both are needed.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Enzalutamide
- Doravirine + Enzalutamide Contraindicated
- Elbasvir / grazoprevir + Enzalutamide Contraindicated
- Ensitrelvir + Enzalutamide Contraindicated
- Enzalutamide + Fostemsavir Contraindicated
- Enzalutamide + Isavuconazonium Contraindicated
- Enzalutamide + Lenacapavir Contraindicated
Other interactions of Encorafenib
Frequently asked questions
Can I take Encorafenib with Enzalutamide?
MediHelp rates the interaction as major. Encorafenib and Enzalutamide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Strong CYP3A4 inducers can lower encorafenib exposure and reduce antitumor efficacy. Enzalutamide is expected to cause this effect.
How serious is the interaction between Encorafenib and Enzalutamide?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concomitant use and select an alternative to enzalutamide if possible. Monitor disease response if both are needed.
What other medicines interact with Enzalutamide?
MediHelp also lists interactions of Enzalutamide with, for example, Doravirine, Elbasvir / grazoprevir, Ensitrelvir. The full list is on the Enzalutamide page.
Full monographs, dosing and an interaction checker in the MediHelp app
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