Drug interactions
Encorafenib + Leflunomide
Severity: Moderate
Encorafenib and Leflunomide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Encorafenib may inhibit BCRP and increase exposure to teriflunomide, the active metabolite of leflunomide. This could heighten hepatotoxicity and other adverse effects.
What this interaction means in plain words
Encorafenib and Leflunomide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Encorafenib belongs to Oncology; Leflunomide belongs to Musculoskeletal.
Why it happens
Encorafenib inhibits the BCRP transporter, which handles teriflunomide.
What to do
Monitor liver enzymes and for teriflunomide adverse effects. Consider leflunomide dose reduction if toxicity arises.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Leflunomide
- Bcg vaccine live + Leflunomide Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Leflunomide Contraindicated
- Leflunomide + Measles mumps and rubella vaccine live Contraindicated
- Leflunomide + Measles mumps rubella and varicella vaccine live Contraindicated
- Leflunomide + Measles vaccine Contraindicated
- Leflunomide + Smallpox vaccine live Contraindicated
Other interactions of Encorafenib
Frequently asked questions
Can I take Encorafenib with Leflunomide?
MediHelp rates the interaction as moderate. Encorafenib and Leflunomide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Encorafenib may inhibit BCRP and increase exposure to teriflunomide, the active metabolite of leflunomide. This could heighten hepatotoxicity and other adverse effects.
How serious is the interaction between Encorafenib and Leflunomide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor liver enzymes and for teriflunomide adverse effects. Consider leflunomide dose reduction if toxicity arises.
What other medicines interact with Leflunomide?
MediHelp also lists interactions of Leflunomide with, for example, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal, Measles mumps and rubella vaccine live. The full list is on the Leflunomide page.
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