Drug interactions
Encorafenib + Medroxyprogesterone
Severity: Moderate
Encorafenib and Medroxyprogesterone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Encorafenib induces CYP3A4 and may reduce medroxyprogesterone exposure, potentially lowering contraceptive or therapeutic efficacy. Encorafenib labeling also warns that hormonal contraceptives may be less effective.
What this interaction means in plain words
Encorafenib and Medroxyprogesterone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Encorafenib belongs to Oncology; Medroxyprogesterone belongs to Endocrine.
Why it happens
Encorafenib induces CYP3A4 (with some inhibition), with net reduction in medroxyprogesterone exposure likely.
What to do
Use an effective non-hormonal contraceptive method during and after encorafenib, and monitor for loss of progestin effect.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Medroxyprogesterone
Other interactions of Encorafenib
Frequently asked questions
Can I take Encorafenib with Medroxyprogesterone?
MediHelp rates the interaction as moderate. Encorafenib and Medroxyprogesterone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Encorafenib induces CYP3A4 and may reduce medroxyprogesterone exposure, potentially lowering contraceptive or therapeutic efficacy. Encorafenib labeling also warns that hormonal contraceptives may be less effective.
How serious is the interaction between Encorafenib and Medroxyprogesterone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use an effective non-hormonal contraceptive method during and after encorafenib, and monitor for loss of progestin effect.
What other medicines interact with Medroxyprogesterone?
MediHelp also lists interactions of Medroxyprogesterone with, for example, Bosentan, Brigatinib, Eslicarbazepine. The full list is on the Medroxyprogesterone page.
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