Drug interactions
Encorafenib + Progesterone
Severity: Moderate
Encorafenib and Progesterone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Encorafenib induces CYP3A4, which may lower progesterone exposure and reduce its effect. Hormonal contraception efficacy may be reduced.
What this interaction means in plain words
Encorafenib and Progesterone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Encorafenib belongs to Oncology; Progesterone belongs to Endocrine.
Why it happens
Encorafenib induces CYP3A4 (with some inhibition), altering progesterone metabolism, with net reduction likely.
What to do
Monitor for reduced progestogenic effect or breakthrough bleeding. Advise an effective non-hormonal contraceptive method when contraception is required.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Progesterone
Other interactions of Encorafenib
Frequently asked questions
Can I take Encorafenib with Progesterone?
MediHelp rates the interaction as moderate. Encorafenib and Progesterone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Encorafenib induces CYP3A4, which may lower progesterone exposure and reduce its effect. Hormonal contraception efficacy may be reduced.
How serious is the interaction between Encorafenib and Progesterone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced progestogenic effect or breakthrough bleeding. Advise an effective non-hormonal contraceptive method when contraception is required.
What other medicines interact with Progesterone?
MediHelp also lists interactions of Progesterone with, for example, Apalutamide, Carbamazepine, Enzalutamide. The full list is on the Progesterone page.
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