Drug interactions
Encorafenib + Vilazodone
Severity: Moderate
Encorafenib and Vilazodone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Encorafenib both inhibits and induces CYP3A4, so vilazodone exposure may rise or fall unpredictably. This could cause adverse effects or reduced antidepressant efficacy.
What this interaction means in plain words
Encorafenib and Vilazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Encorafenib belongs to Oncology; Vilazodone belongs to Central Nervous System.
Why it happens
Mixed CYP3A4 inhibition and induction by encorafenib altering vilazodone metabolism.
What to do
Monitor for both vilazodone toxicity and loss of response. Adjust the vilazodone dose according to clinical effect.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Vilazodone
- Isocarboxazid + Vilazodone Contraindicated
- Methylene blue + Vilazodone Contraindicated
- Phenelzine + Vilazodone Contraindicated
- Rasagiline + Vilazodone Contraindicated
- Selegiline transdermal + Vilazodone Contraindicated
- Selegiline + Vilazodone Contraindicated
Other interactions of Encorafenib
Frequently asked questions
Can I take Encorafenib with Vilazodone?
MediHelp rates the interaction as moderate. Encorafenib and Vilazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Encorafenib both inhibits and induces CYP3A4, so vilazodone exposure may rise or fall unpredictably. This could cause adverse effects or reduced antidepressant efficacy.
How serious is the interaction between Encorafenib and Vilazodone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for both vilazodone toxicity and loss of response. Adjust the vilazodone dose according to clinical effect.
What other medicines interact with Vilazodone?
MediHelp also lists interactions of Vilazodone with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Vilazodone page.
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