Drug interactions
Enfortumab vedotin + Isoniazid
Severity: Moderate
Enfortumab vedotin and Isoniazid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Free MMAE released from enfortumab vedotin is a CYP3A4 substrate, and strong CYP3A4 inhibitors may raise its exposure and toxicity. Isoniazid is a weak inhibitor, so any effect is likely small, but peripheral neuropathy is a shared toxicity of the two drugs.
What this interaction means in plain words
Enfortumab vedotin and Isoniazid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Enfortumab vedotin belongs to Oncology; Isoniazid belongs to Anti Bacterial.
Why it happens
Possible CYP3A4 inhibition reducing MMAE clearance, plus additive neurotoxicity.
What to do
Monitor for neuropathy, neutropenia and skin reactions, and give pyridoxine with isoniazid as usual. Interrupt or reduce enfortumab vedotin per labeling if toxicity develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Enfortumab vedotin and Isoniazid, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Isoniazid
Other interactions of Enfortumab vedotin
- Chloramphenicol + Enfortumab vedotin Moderate
- Clarithromycin + Enfortumab vedotin Moderate
- Enfortumab vedotin + Itraconazole Moderate
- Enfortumab vedotin + Ketoconazole Moderate
- Enfortumab vedotin + Mifepristone Moderate
- Enfortumab vedotin + Posaconazole Moderate
Frequently asked questions
Can I take Enfortumab vedotin with Isoniazid?
MediHelp rates the interaction as moderate. Enfortumab vedotin and Isoniazid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Free MMAE released from enfortumab vedotin is a CYP3A4 substrate, and strong CYP3A4 inhibitors may raise its exposure and toxicity. Isoniazid is a weak inhibitor, so any effect is likely small, but peripheral neuropathy is a shared toxicity of the two drugs.
How serious is the interaction between Enfortumab vedotin and Isoniazid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for neuropathy, neutropenia and skin reactions, and give pyridoxine with isoniazid as usual. Interrupt or reduce enfortumab vedotin per labeling if toxicity develops.
What other medicines interact with Isoniazid?
MediHelp also lists interactions of Isoniazid with, for example, Bacillus calmette-guerin substrain tice, Benzhydrocodone / acetaminophen, Carbamazepine. The full list is on the Isoniazid page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
