Drug interactions
Clarithromycin + Enfortumab vedotin
Severity: Moderate
Clarithromycin and Enfortumab vedotin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Clarithromycin may increase exposure to free MMAE, the cytotoxic payload of enfortumab vedotin. This could increase toxicities such as neutropenia, neuropathy and skin reactions.
What this interaction means in plain words
Clarithromycin and Enfortumab vedotin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clarithromycin belongs to Anti Bacterial; Enfortumab vedotin belongs to Oncology.
Why it happens
Clarithromycin inhibits CYP3A4 and P-glycoprotein, both involved in MMAE clearance.
What to do
Monitor closely for neutropenia, peripheral neuropathy and skin reactions. Prefer a non-inhibiting antibiotic if possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clarithromycin
- Astemizole + Clarithromycin Contraindicated
- Avanafil + Clarithromycin Contraindicated
- Cisapride + Clarithromycin Contraindicated
- Clarithromycin + Colchicine Contraindicated
- Clarithromycin + Conivaptan Contraindicated
- Clarithromycin + Dihydroergotamine Contraindicated
Other interactions of Enfortumab vedotin
- Chloramphenicol + Enfortumab vedotin Moderate
- Enfortumab vedotin + Isoniazid Moderate
- Enfortumab vedotin + Itraconazole Moderate
- Enfortumab vedotin + Ketoconazole Moderate
- Enfortumab vedotin + Mifepristone Moderate
- Enfortumab vedotin + Posaconazole Moderate
Frequently asked questions
Can I take Clarithromycin with Enfortumab vedotin?
MediHelp rates the interaction as moderate. Clarithromycin and Enfortumab vedotin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Clarithromycin may increase exposure to free MMAE, the cytotoxic payload of enfortumab vedotin. This could increase toxicities such as neutropenia, neuropathy and skin reactions.
How serious is the interaction between Clarithromycin and Enfortumab vedotin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor closely for neutropenia, peripheral neuropathy and skin reactions. Prefer a non-inhibiting antibiotic if possible.
What other medicines interact with Clarithromycin?
MediHelp also lists interactions of Clarithromycin with, for example, Astemizole, Avanafil, Cisapride. The full list is on the Clarithromycin page.
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