Drug interactions
Enfortumab vedotin + Posaconazole
Severity: Moderate
Enfortumab vedotin and Posaconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
The cytotoxic payload of enfortumab vedotin, MMAE, is metabolized by CYP3A4 and is a P-gp substrate. Posaconazole inhibits both, which may increase MMAE exposure and the risk of toxicities such as neutropenia, neuropathy and severe skin reactions.
What this interaction means in plain words
Enfortumab vedotin and Posaconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Enfortumab vedotin belongs to Oncology; Posaconazole belongs to Anti Fungals.
Why it happens
Posaconazole inhibits CYP3A4 and P-gp, reducing clearance of free MMAE.
What to do
Monitor closely for adverse reactions including skin toxicity, neuropathy and hyperglycemia. Withhold or modify enfortumab vedotin per labeling if toxicity develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Posaconazole
- Artemether + Posaconazole Contraindicated
- Avanafil + Posaconazole Contraindicated
- Cobimetinib + Posaconazole Contraindicated
- Conivaptan + Posaconazole Contraindicated
- Dihydroergotamine intranasal + Posaconazole Contraindicated
- Dihydroergotamine + Posaconazole Contraindicated
Other interactions of Enfortumab vedotin
- Chloramphenicol + Enfortumab vedotin Moderate
- Clarithromycin + Enfortumab vedotin Moderate
- Enfortumab vedotin + Isoniazid Moderate
- Enfortumab vedotin + Itraconazole Moderate
- Enfortumab vedotin + Ketoconazole Moderate
- Enfortumab vedotin + Mifepristone Moderate
Frequently asked questions
Can I take Enfortumab vedotin with Posaconazole?
MediHelp rates the interaction as moderate. Enfortumab vedotin and Posaconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. The cytotoxic payload of enfortumab vedotin, MMAE, is metabolized by CYP3A4 and is a P-gp substrate. Posaconazole inhibits both, which may increase MMAE exposure and the risk of toxicities such as neutropenia, neuropathy and severe skin reactions.
How serious is the interaction between Enfortumab vedotin and Posaconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor closely for adverse reactions including skin toxicity, neuropathy and hyperglycemia. Withhold or modify enfortumab vedotin per labeling if toxicity develops.
What other medicines interact with Posaconazole?
MediHelp also lists interactions of Posaconazole with, for example, Artemether, Avanafil, Cobimetinib. The full list is on the Posaconazole page.
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