Drug interactions
Enfortumab vedotin + Itraconazole
Severity: Moderate
Enfortumab vedotin and Itraconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Itraconazole may raise free MMAE, the cytotoxic payload of enfortumab vedotin, increasing toxicities such as neutropenia, peripheral neuropathy and severe skin reactions. The effect is most relevant with strong CYP3A4 and P-gp inhibitors.
What this interaction means in plain words
Enfortumab vedotin and Itraconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Enfortumab vedotin belongs to Oncology; Itraconazole belongs to Anti Fungals.
Why it happens
Inhibition of CYP3A4 and P-glycoprotein reduces MMAE clearance.
What to do
Monitor closely for neutropenia, neuropathy and skin reactions. Interrupt or reduce enfortumab vedotin if serious toxicity occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Itraconazole
- Alfuzosin + Itraconazole Contraindicated
- Alprazolam + Itraconazole Contraindicated
- Avanafil + Itraconazole Contraindicated
- Conivaptan + Itraconazole Contraindicated
- Dihydroergotamine intranasal + Itraconazole Contraindicated
- Dihydroergotamine + Itraconazole Contraindicated
Other interactions of Enfortumab vedotin
- Chloramphenicol + Enfortumab vedotin Moderate
- Clarithromycin + Enfortumab vedotin Moderate
- Enfortumab vedotin + Isoniazid Moderate
- Enfortumab vedotin + Ketoconazole Moderate
- Enfortumab vedotin + Mifepristone Moderate
- Enfortumab vedotin + Posaconazole Moderate
Frequently asked questions
Can I take Enfortumab vedotin with Itraconazole?
MediHelp rates the interaction as moderate. Enfortumab vedotin and Itraconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Itraconazole may raise free MMAE, the cytotoxic payload of enfortumab vedotin, increasing toxicities such as neutropenia, peripheral neuropathy and severe skin reactions. The effect is most relevant with strong CYP3A4 and P-gp inhibitors.
How serious is the interaction between Enfortumab vedotin and Itraconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor closely for neutropenia, neuropathy and skin reactions. Interrupt or reduce enfortumab vedotin if serious toxicity occurs.
What other medicines interact with Itraconazole?
MediHelp also lists interactions of Itraconazole with, for example, Alfuzosin, Alprazolam, Avanafil. The full list is on the Itraconazole page.
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