Drug interactions
Enfortumab vedotin + Ketoconazole
Severity: Moderate
Enfortumab vedotin and Ketoconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ketoconazole can increase exposure to free MMAE, the cytotoxic payload of enfortumab vedotin. This may increase toxicities such as neutropenia, neuropathy and skin reactions.
What this interaction means in plain words
Enfortumab vedotin and Ketoconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Enfortumab vedotin belongs to Oncology; Ketoconazole belongs to Anti Fungals.
Why it happens
Ketoconazole inhibits CYP3A4 and P-glycoprotein, which clear MMAE.
What to do
Monitor closely for adverse reactions such as neutropenia, peripheral neuropathy and skin toxicity. Interrupt or reduce enfortumab vedotin according to its labeling if toxicity develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ketoconazole
- Alfuzosin + Ketoconazole Contraindicated
- Alprazolam + Ketoconazole Contraindicated
- Avanafil + Ketoconazole Contraindicated
- Conivaptan + Ketoconazole Contraindicated
- Dihydroergotamine intranasal + Ketoconazole Contraindicated
- Dihydroergotamine + Ketoconazole Contraindicated
Other interactions of Enfortumab vedotin
- Chloramphenicol + Enfortumab vedotin Moderate
- Clarithromycin + Enfortumab vedotin Moderate
- Enfortumab vedotin + Isoniazid Moderate
- Enfortumab vedotin + Itraconazole Moderate
- Enfortumab vedotin + Mifepristone Moderate
- Enfortumab vedotin + Posaconazole Moderate
Frequently asked questions
Can I take Enfortumab vedotin with Ketoconazole?
MediHelp rates the interaction as moderate. Enfortumab vedotin and Ketoconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ketoconazole can increase exposure to free MMAE, the cytotoxic payload of enfortumab vedotin. This may increase toxicities such as neutropenia, neuropathy and skin reactions.
How serious is the interaction between Enfortumab vedotin and Ketoconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor closely for adverse reactions such as neutropenia, peripheral neuropathy and skin toxicity. Interrupt or reduce enfortumab vedotin according to its labeling if toxicity develops.
What other medicines interact with Ketoconazole?
MediHelp also lists interactions of Ketoconazole with, for example, Alfuzosin, Alprazolam, Avanafil. The full list is on the Ketoconazole page.
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