Drug interactions
Chloramphenicol + Enfortumab vedotin
Severity: Moderate
Chloramphenicol and Enfortumab vedotin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Enfortumab vedotin releases monomethyl auristatin E, which is cleared mainly by CYP3A4. A CYP3A4 inhibitor such as chloramphenicol could raise free MMAE exposure and increase toxicities such as neuropathy, myelosuppression, and skin reactions.
What this interaction means in plain words
Chloramphenicol and Enfortumab vedotin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chloramphenicol belongs to Anti Bacterial; Enfortumab vedotin belongs to Oncology.
Why it happens
Inhibition of CYP3A4-mediated metabolism of MMAE, the cytotoxic payload.
What to do
Monitor closely for adverse reactions including neutropenia, peripheral neuropathy, and severe skin reactions. Consider an alternative antibiotic when possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chloramphenicol
Other interactions of Enfortumab vedotin
- Clarithromycin + Enfortumab vedotin Moderate
- Enfortumab vedotin + Isoniazid Moderate
- Enfortumab vedotin + Itraconazole Moderate
- Enfortumab vedotin + Ketoconazole Moderate
- Enfortumab vedotin + Mifepristone Moderate
- Enfortumab vedotin + Posaconazole Moderate
Frequently asked questions
Can I take Chloramphenicol with Enfortumab vedotin?
MediHelp rates the interaction as moderate. Chloramphenicol and Enfortumab vedotin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Enfortumab vedotin releases monomethyl auristatin E, which is cleared mainly by CYP3A4. A CYP3A4 inhibitor such as chloramphenicol could raise free MMAE exposure and increase toxicities such as neuropathy, myelosuppression, and skin reactions.
How serious is the interaction between Chloramphenicol and Enfortumab vedotin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor closely for adverse reactions including neutropenia, peripheral neuropathy, and severe skin reactions. Consider an alternative antibiotic when possible.
What other medicines interact with Chloramphenicol?
MediHelp also lists interactions of Chloramphenicol with, for example, Adagrasib, Avapritinib, Bcg vaccine live. The full list is on the Chloramphenicol page.
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