Drug interactions
Enfortumab vedotin + Phenytoin
Severity: Minor
Enfortumab vedotin and Phenytoin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Phenytoin may reduce exposure to the MMAE payload of enfortumab vedotin through CYP3A4 induction. The effect on efficacy is not established and intact conjugate is not affected.
What this interaction means in plain words
Enfortumab vedotin and Phenytoin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Enfortumab vedotin belongs to Oncology; Phenytoin belongs to Central Nervous System.
Why it happens
CYP3A4 induction by phenytoin may increase clearance of free MMAE.
What to do
No empirical dose adjustment is needed; monitor for reduced antitumor response during prolonged coadministration.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Phenytoin
- Artemether / lumefantrine + Phenytoin Contraindicated
- Bictegravir + Phenytoin Contraindicated
- Cabotegravir + Phenytoin Contraindicated
- Doravirine + Phenytoin Contraindicated
- Elbasvir / grazoprevir + Phenytoin Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Phenytoin Contraindicated
Other interactions of Enfortumab vedotin
- Chloramphenicol + Enfortumab vedotin Moderate
- Clarithromycin + Enfortumab vedotin Moderate
- Enfortumab vedotin + Isoniazid Moderate
- Enfortumab vedotin + Itraconazole Moderate
- Enfortumab vedotin + Ketoconazole Moderate
- Enfortumab vedotin + Mifepristone Moderate
Frequently asked questions
Can I take Enfortumab vedotin with Phenytoin?
MediHelp rates the interaction as minor. Enfortumab vedotin and Phenytoin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Phenytoin may reduce exposure to the MMAE payload of enfortumab vedotin through CYP3A4 induction. The effect on efficacy is not established and intact conjugate is not affected.
How serious is the interaction between Enfortumab vedotin and Phenytoin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No empirical dose adjustment is needed; monitor for reduced antitumor response during prolonged coadministration.
What other medicines interact with Phenytoin?
MediHelp also lists interactions of Phenytoin with, for example, Artemether / lumefantrine, Bictegravir, Cabotegravir. The full list is on the Phenytoin page.
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