Drug interactions
Enoxaparin + Hemin
Severity: Moderate
Enoxaparin and Hemin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hemin breaks down to hematin, which has been associated with transient coagulopathy and a mild anticoagulant effect. Given together with enoxaparin, this may add to the risk of bleeding.
What this interaction means in plain words
Enoxaparin and Hemin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Enoxaparin belongs to Cardiovascular; Hemin belongs to Miscellaneous.
Why it happens
Additive pharmacodynamic effect on hemostasis: hematin has weak anticoagulant and platelet-impairing activity, while enoxaparin potentiates antithrombin.
What to do
Monitor for bleeding and platelet count during and after hemin infusion. Reassess the enoxaparin dose or timing if bleeding or coagulopathy develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Enoxaparin
- Defibrotide + Enoxaparin Contraindicated
- Enoxaparin + Ketorolac Contraindicated
- Enoxaparin + Mifepristone Contraindicated
- Abciximab + Enoxaparin Major
- Aceclofenac + Enoxaparin Major
- Acetylsalicylic acid + Enoxaparin Major
Other interactions of Hemin
- Hemin + Secobarbital Major
- Argatroban + Hemin Moderate
- Bazedoxifene-conjugated estrogens + Hemin Moderate
- Dabigatran etexilate + Hemin Moderate
- Dalteparin + Hemin Moderate
- Desogestrel-ethinyl estradiol + Hemin Moderate
Frequently asked questions
Can I take Enoxaparin with Hemin?
MediHelp rates the interaction as moderate. Enoxaparin and Hemin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Hemin breaks down to hematin, which has been associated with transient coagulopathy and a mild anticoagulant effect. Given together with enoxaparin, this may add to the risk of bleeding.
How serious is the interaction between Enoxaparin and Hemin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for bleeding and platelet count during and after hemin infusion. Reassess the enoxaparin dose or timing if bleeding or coagulopathy develops.
What other medicines interact with Enoxaparin?
MediHelp also lists interactions of Enoxaparin with, for example, Defibrotide, Ketorolac, Mifepristone. The full list is on the Enoxaparin page.
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