Drug interactions
Enoxaparin + Hydrochlorothiazide-irbesartan
Severity: Moderate
Enoxaparin and Hydrochlorothiazide-irbesartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Enoxaparin can suppress aldosterone secretion and cause hyperkalemia, which may add to the potassium-retaining effect of irbesartan. The thiazide component partly counteracts this, but the risk remains in patients with renal impairment or diabetes.
What this interaction means in plain words
Enoxaparin and Hydrochlorothiazide-irbesartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Enoxaparin belongs to Cardiovascular; Hydrochlorothiazide-irbesartan belongs to Cardiovascular.
Why it happens
Heparin-induced suppression of adrenal aldosterone synthesis adds to angiotensin receptor blockade.
What to do
Monitor serum potassium, especially with treatment beyond several days or with renal impairment. Manage hyperkalemia if it occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-irbesartan
- Aliskiren + Hydrochlorothiazide-irbesartan Contraindicated
- Dofetilide + Hydrochlorothiazide-irbesartan Contraindicated
- Hydrochlorothiazide-irbesartan + Sparsentan Contraindicated
- Aldesleukin + Hydrochlorothiazide-irbesartan Major
- Amifostine + Hydrochlorothiazide-irbesartan Major
- Amiloride + Hydrochlorothiazide-irbesartan Major
Other interactions of Enoxaparin
- Defibrotide + Enoxaparin Contraindicated
- Enoxaparin + Ketorolac Contraindicated
- Enoxaparin + Mifepristone Contraindicated
- Abciximab + Enoxaparin Major
- Aceclofenac + Enoxaparin Major
- Acetylsalicylic acid + Enoxaparin Major
Frequently asked questions
Can I take Enoxaparin with Hydrochlorothiazide-irbesartan?
MediHelp rates the interaction as moderate. Enoxaparin and Hydrochlorothiazide-irbesartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Enoxaparin can suppress aldosterone secretion and cause hyperkalemia, which may add to the potassium-retaining effect of irbesartan. The thiazide component partly counteracts this, but the risk remains in patients with renal impairment or diabetes.
How serious is the interaction between Enoxaparin and Hydrochlorothiazide-irbesartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium, especially with treatment beyond several days or with renal impairment. Manage hyperkalemia if it occurs.
What other medicines interact with Hydrochlorothiazide-irbesartan?
MediHelp also lists interactions of Hydrochlorothiazide-irbesartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-irbesartan page.
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