Drug interactions
Enoxaparin + Vortioxetine
Severity: Moderate
Enoxaparin and Vortioxetine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vortioxetine, like other serotonergic antidepressants, can impair platelet function and raise the risk of bleeding. With enoxaparin the bleeding risk, particularly gastrointestinal, may be higher.
What this interaction means in plain words
Enoxaparin and Vortioxetine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Enoxaparin belongs to Cardiovascular; Vortioxetine belongs to Central Nervous System.
Why it happens
Vortioxetine inhibits platelet serotonin reuptake and so reduces platelet aggregation, adding to the anticoagulant effect of enoxaparin.
What to do
Monitor for signs of bleeding such as bruising, melaena or haematuria, especially in older patients or those with other bleeding risks. Consider gastroprotection when risk is high.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Enoxaparin
- Defibrotide + Enoxaparin Contraindicated
- Enoxaparin + Ketorolac Contraindicated
- Enoxaparin + Mifepristone Contraindicated
- Abciximab + Enoxaparin Major
- Aceclofenac + Enoxaparin Major
- Acetylsalicylic acid + Enoxaparin Major
Other interactions of Vortioxetine
- Isocarboxazid + Vortioxetine Contraindicated
- Linezolid + Vortioxetine Contraindicated
- Methylene blue + Vortioxetine Contraindicated
- Phenelzine + Vortioxetine Contraindicated
- Rasagiline + Vortioxetine Contraindicated
- Selegiline transdermal + Vortioxetine Contraindicated
Frequently asked questions
Can I take Enoxaparin with Vortioxetine?
MediHelp rates the interaction as moderate. Enoxaparin and Vortioxetine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Vortioxetine, like other serotonergic antidepressants, can impair platelet function and raise the risk of bleeding. With enoxaparin the bleeding risk, particularly gastrointestinal, may be higher.
How serious is the interaction between Enoxaparin and Vortioxetine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of bleeding such as bruising, melaena or haematuria, especially in older patients or those with other bleeding risks. Consider gastroprotection when risk is high.
What other medicines interact with Enoxaparin?
MediHelp also lists interactions of Enoxaparin with, for example, Defibrotide, Ketorolac, Mifepristone. The full list is on the Enoxaparin page.
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