Drug interactions
Entacapone + Isoproterenol
Severity: Moderate
Entacapone and Isoproterenol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Isoproterenol is partly metabolized by COMT, so entacapone can raise its levels and prolong its effects. This may cause excessive tachycardia, arrhythmia and changes in blood pressure.
What this interaction means in plain words
Entacapone and Isoproterenol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Entacapone belongs to Central Nervous System; Isoproterenol belongs to Respiratory.
Why it happens
COMT inhibition by entacapone slows the metabolism of isoproterenol.
What to do
Monitor heart rate, rhythm and blood pressure continuously during isoproterenol therapy. Titrate to the lowest effective dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Entacapone
- Entacapone + Isocarboxazid Contraindicated
- Entacapone + Phenelzine Contraindicated
- Entacapone + Tranylcypromine Contraindicated
- Amisulpride + Entacapone Major
- Entacapone + Metoclopramide Major
- Entacapone + Metoclopramide intranasal Major
Other interactions of Isoproterenol
Frequently asked questions
Can I take Entacapone with Isoproterenol?
MediHelp rates the interaction as moderate. Entacapone and Isoproterenol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Isoproterenol is partly metabolized by COMT, so entacapone can raise its levels and prolong its effects. This may cause excessive tachycardia, arrhythmia and changes in blood pressure.
How serious is the interaction between Entacapone and Isoproterenol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate, rhythm and blood pressure continuously during isoproterenol therapy. Titrate to the lowest effective dose.
What other medicines interact with Entacapone?
MediHelp also lists interactions of Entacapone with, for example, Isocarboxazid, Phenelzine, Tranylcypromine. The full list is on the Entacapone page.
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