Drug interactions
Entacapone + Levetiracetam
Severity: Minor
Entacapone and Levetiracetam: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Levetiracetam frequently causes somnolence, dizziness and fatigue, and entacapone can add to these effects. The combination may impair alertness and increase fall risk.
What this interaction means in plain words
Entacapone and Levetiracetam have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Entacapone belongs to Central Nervous System; Levetiracetam belongs to Central Nervous System.
Why it happens
Additive central nervous system depressant effects.
What to do
Counsel patients about drowsiness and driving. Reduce the dose if sedation is excessive.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Entacapone
- Entacapone + Isocarboxazid Contraindicated
- Entacapone + Phenelzine Contraindicated
- Entacapone + Tranylcypromine Contraindicated
- Amisulpride + Entacapone Major
- Entacapone + Metoclopramide Major
- Entacapone + Metoclopramide intranasal Major
Other interactions of Levetiracetam
Frequently asked questions
Can I take Entacapone with Levetiracetam?
MediHelp rates the interaction as minor. Entacapone and Levetiracetam have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Levetiracetam frequently causes somnolence, dizziness and fatigue, and entacapone can add to these effects. The combination may impair alertness and increase fall risk.
How serious is the interaction between Entacapone and Levetiracetam?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel patients about drowsiness and driving. Reduce the dose if sedation is excessive.
What other medicines interact with Entacapone?
MediHelp also lists interactions of Entacapone with, for example, Isocarboxazid, Phenelzine, Tranylcypromine. The full list is on the Entacapone page.
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