Drug interactions
Entacapone + Oliceridine
Severity: Minor
Entacapone and Oliceridine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oliceridine is metabolized by CYP3A4 and CYP2D6, and CYP3A4 inhibitors can raise exposure, increasing sedation and respiratory depression. Entacapone is not a proven CYP3A4 inhibitor, so the effect is likely small, though the opioid risk warrants attention.
What this interaction means in plain words
Entacapone and Oliceridine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Entacapone belongs to Central Nervous System; Oliceridine belongs to Musculoskeletal.
Why it happens
Theoretical CYP3A4 inhibition by entacapone reducing oliceridine clearance.
What to do
Titrate oliceridine to effect and monitor for sedation and respiratory depression. Reassess dosing if the combination is started or stopped.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Entacapone
- Entacapone + Isocarboxazid Contraindicated
- Entacapone + Phenelzine Contraindicated
- Entacapone + Tranylcypromine Contraindicated
- Amisulpride + Entacapone Major
- Entacapone + Metoclopramide Major
- Entacapone + Metoclopramide intranasal Major
Other interactions of Oliceridine
- Isocarboxazid + Oliceridine Contraindicated
- Alprazolam + Oliceridine Major
- Amiodarone + Oliceridine Major
- Amisulpride + Oliceridine Major
- Amitriptyline + Oliceridine Major
- Amobarbital + Oliceridine Major
Frequently asked questions
Can I take Entacapone with Oliceridine?
MediHelp rates the interaction as minor. Entacapone and Oliceridine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Oliceridine is metabolized by CYP3A4 and CYP2D6, and CYP3A4 inhibitors can raise exposure, increasing sedation and respiratory depression. Entacapone is not a proven CYP3A4 inhibitor, so the effect is likely small, though the opioid risk warrants attention.
How serious is the interaction between Entacapone and Oliceridine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate oliceridine to effect and monitor for sedation and respiratory depression. Reassess dosing if the combination is started or stopped.
What other medicines interact with Entacapone?
MediHelp also lists interactions of Entacapone with, for example, Isocarboxazid, Phenelzine, Tranylcypromine. The full list is on the Entacapone page.
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