Drug interactions
Entacapone + Voclosporin
Severity: Minor
Entacapone and Voclosporin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Voclosporin is a CYP3A4 substrate with a narrow therapeutic range, and CYP3A4 inhibitors raise exposure and the risk of nephrotoxicity, hypertension and hyperkalemia. Entacapone is not an established CYP3A4 inhibitor, so a significant effect is not expected.
What this interaction means in plain words
Entacapone and Voclosporin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Entacapone belongs to Central Nervous System; Voclosporin belongs to Miscellaneous.
Why it happens
Theoretical CYP3A4 inhibition by entacapone.
What to do
Monitor eGFR, blood pressure and potassium per voclosporin labeling. No empirical dose change is needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Entacapone
- Entacapone + Isocarboxazid Contraindicated
- Entacapone + Phenelzine Contraindicated
- Entacapone + Tranylcypromine Contraindicated
- Amisulpride + Entacapone Major
- Entacapone + Metoclopramide Major
- Entacapone + Metoclopramide intranasal Major
Other interactions of Voclosporin
- Clarithromycin + Voclosporin Contraindicated
- Cyclosporin + Voclosporin Contraindicated
- Ensitrelvir + Voclosporin Contraindicated
- Itraconazole + Voclosporin Contraindicated
- Ketoconazole + Voclosporin Contraindicated
- Posaconazole + Voclosporin Contraindicated
Frequently asked questions
Can I take Entacapone with Voclosporin?
MediHelp rates the interaction as minor. Entacapone and Voclosporin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Voclosporin is a CYP3A4 substrate with a narrow therapeutic range, and CYP3A4 inhibitors raise exposure and the risk of nephrotoxicity, hypertension and hyperkalemia. Entacapone is not an established CYP3A4 inhibitor, so a significant effect is not expected.
How serious is the interaction between Entacapone and Voclosporin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor eGFR, blood pressure and potassium per voclosporin labeling. No empirical dose change is needed.
What other medicines interact with Entacapone?
MediHelp also lists interactions of Entacapone with, for example, Isocarboxazid, Phenelzine, Tranylcypromine. The full list is on the Entacapone page.
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