Drug interactions
Entacapone + Warfarin
Severity: Minor
Entacapone and Warfarin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Entacapone may modestly raise the anticoagulant effect of warfarin. Documented changes in INR are small, but a few patients may need a dose change.
What this interaction means in plain words
Entacapone and Warfarin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Entacapone belongs to Central Nervous System; Warfarin belongs to Cardiovascular.
Why it happens
The mechanism is not established; entacapone has been reported to affect R-warfarin handling, with little change in S-warfarin.
What to do
Check INR when entacapone is started or stopped and adjust warfarin only if the INR moves out of range.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Warfarin
- Defibrotide + Warfarin Contraindicated
- Ketorolac + Warfarin Contraindicated
- Abciximab + Warfarin Major
- Acetylsalicylic acid + Warfarin Major
- Adagrasib + Warfarin Major
- Amiodarone + Warfarin Major
Other interactions of Entacapone
- Entacapone + Isocarboxazid Contraindicated
- Entacapone + Phenelzine Contraindicated
- Entacapone + Tranylcypromine Contraindicated
- Amisulpride + Entacapone Major
- Entacapone + Metoclopramide Major
- Entacapone + Metoclopramide intranasal Major
Frequently asked questions
Can I take Entacapone with Warfarin?
MediHelp rates the interaction as minor. Entacapone and Warfarin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Entacapone may modestly raise the anticoagulant effect of warfarin. Documented changes in INR are small, but a few patients may need a dose change.
How serious is the interaction between Entacapone and Warfarin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check INR when entacapone is started or stopped and adjust warfarin only if the INR moves out of range.
What other medicines interact with Warfarin?
MediHelp also lists interactions of Warfarin with, for example, Defibrotide, Ketorolac, Abciximab. The full list is on the Warfarin page.
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