Drug interactions
Entecavir + Eprosartan-hydrochlorothiazide
Severity: Minor
Entecavir and Eprosartan-hydrochlorothiazide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Entecavir is eliminated by the kidney through filtration and tubular secretion, so drugs that impair renal function or compete for secretion may raise its levels. The effect with this combination is expected to be small, though thiazide-related volume depletion could reduce renal function.
What this interaction means in plain words
Entecavir and Eprosartan-hydrochlorothiazide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Entecavir belongs to Anti Virals; Eprosartan-hydrochlorothiazide belongs to Cardiovascular.
Why it happens
Possible competition for renal tubular secretion and reduced renal clearance from volume depletion.
What to do
Monitor renal function and adjust entecavir dose to creatinine clearance if function declines.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Eprosartan-hydrochlorothiazide
- Aliskiren + Eprosartan-hydrochlorothiazide Contraindicated
- Dofetilide + Eprosartan-hydrochlorothiazide Contraindicated
- Eprosartan-hydrochlorothiazide + Sparsentan Contraindicated
- Aceclofenac + Eprosartan-hydrochlorothiazide Major
- Aldesleukin + Eprosartan-hydrochlorothiazide Major
- Amifostine + Eprosartan-hydrochlorothiazide Major
Other interactions of Entecavir
Frequently asked questions
Can I take Entecavir with Eprosartan-hydrochlorothiazide?
MediHelp rates the interaction as minor. Entecavir and Eprosartan-hydrochlorothiazide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Entecavir is eliminated by the kidney through filtration and tubular secretion, so drugs that impair renal function or compete for secretion may raise its levels. The effect with this combination is expected to be small, though thiazide-related volume depletion could reduce renal function.
How serious is the interaction between Entecavir and Eprosartan-hydrochlorothiazide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor renal function and adjust entecavir dose to creatinine clearance if function declines.
What other medicines interact with Eprosartan-hydrochlorothiazide?
MediHelp also lists interactions of Eprosartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Eprosartan-hydrochlorothiazide page.
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